Can I go straight from the Brooks Glycerin 20 to the Glycerin 22 and skip the Glycerin 21?

Yes, but going Glycerin 20 to Glycerin 22 means taking one change in a single step: the Glycerin 22 is where the ride moved. Drop holds at 10 mm, so the difference is foam and fit rather than geometry: Nitrogen-infused DNA Loft v3 to DNA Tuned supercritical foam.

How much did the weight change across these two updates?

0.3 oz off in total, 10.5 oz to 10.2 oz in a men's US 9. The Glycerin 21 took it to 9.8 oz first.

Is the Glycerin 21 the better buy than either of these?

On paper it splits them: 9.8 oz against 10.5 oz for the Glycerin 20 and 10.2 oz for the Glycerin 22, on a 38 mm heel and a $160 list price. Availability decides it: Amazon's Glycerin 21 stock is gone in both men's and women's sizes, so it is not a live option.

Did the Glycerin get taller between the Glycerin 20 and the Glycerin 22?

Heel stack went 34 mm to 38 mm, by way of 38 mm on the Glycerin 21. Drop held at 10 mm throughout, so the extra foam sits under both ends.

Where does the Glycerin 22 sit in the Glycerin lineup now?

Two versions on from the Glycerin 20, and already replaced itself: the Glycerin 23 arrived in 2026. If you are shopping old stock anyway, price the Glycerin 22 against it before deciding.

Brooks Glycerin 20 vs Glycerin 22

Two versions apart. Updated September 10, 2026. Specs are men's US 9.

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THE SHORT ANSWER

Two updates and 3 years separate the Brooks Glycerin 20 from the Glycerin 22. Net change: 0.3 oz lighter, 4 mm more heel stack, a new midsole, $5 more at list. The Glycerin 22 is where the character changed, and that is the update Glycerin 20 owners notice first.

Brooks Glycerin 20Sizes running outMen's at Amazon Women's
Brooks Glycerin 22Men's at Amazon Women's

Availability last checked Sep 10, 2026. Prices and stock change without notice.

Glycerin 20 · 2022

Glycerin 22 · 2025

The two updates in between

Each step has its own page with the full change list and the verdict on that update.

Step 1Glycerin 20 to Glycerin 212023Refined, same shoe
Glycerin 20 vs 21 What replaced the Brooks Glycerin 20?
Step 2Glycerin 21 to Glycerin 222025Changed character
Glycerin 21 vs 22 What replaced the Brooks Glycerin 21?

Glycerin 20 vs Glycerin 22: every spec, side by side

The net of both updates. Per-update change notes stay on the step pages above, because they explain changes measured from a different starting point than this table uses.

Spec	Glycerin 20	Glycerin 22
FIT AND WEIGHT
Weight	10.5 oz	10.2 oz
Widths	D, 2E	D, 2E, 4E
Upper	Engineered mesh (StealthFit knit variant also offered)	Engineered mesh
CUSHIONING GEOMETRY
Heel stack	34 mm	38 mm
Forefoot stack	24 mm	28 mm
Drop	10 mm	10 mm
MATERIALS
Midsole	Nitrogen-infused DNA Loft v3	DNA Tuned supercritical foam
VALUE
List price at launch	$160	$165

Or buy the Glycerin 21 instead?

The Glycerin 21 is not a live option: Amazon's stock is gone in both men's and women's sizes. This is a two-shoe decision between remaining Glycerin 20 pairs and the Glycerin 22.

Buy the Glycerin 21

Old stock gone

Amazon's stock of the Brooks Glycerin 21 is gone in both men's and women's sizes, and discontinued stock does not come back.

Old stock is gone. See what replaced it

Questions runners ask

Can I go straight from the Brooks Glycerin 20 to the Glycerin 22 and skip the Glycerin 21?: Yes, but going Glycerin 20 to Glycerin 22 means taking one change in a single step: the Glycerin 22 is where the ride moved. Drop holds at 10 mm, so the difference is foam and fit rather than geometry: Nitrogen-infused DNA Loft v3 to DNA Tuned supercritical foam.
How much did the weight change across these two updates?: 0.3 oz off in total, 10.5 oz to 10.2 oz in a men's US 9. The Glycerin 21 took it to 9.8 oz first.
Is the Glycerin 21 the better buy than either of these?: On paper it splits them: 9.8 oz against 10.5 oz for the Glycerin 20 and 10.2 oz for the Glycerin 22, on a 38 mm heel and a $160 list price. Availability decides it: Amazon's Glycerin 21 stock is gone in both men's and women's sizes, so it is not a live option.
Did the Glycerin get taller between the Glycerin 20 and the Glycerin 22?: Heel stack went 34 mm to 38 mm, by way of 38 mm on the Glycerin 21. Drop held at 10 mm throughout, so the extra foam sits under both ends.
Where does the Glycerin 22 sit in the Glycerin lineup now?: Two versions on from the Glycerin 20, and already replaced itself: the Glycerin 23 arrived in 2026. If you are shopping old stock anyway, price the Glycerin 22 against it before deciding.